Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo
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چکیده
منابع مشابه
Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture
Elastic system fibers consist of microfibrils and tropoelastin. During development, microfibrils act as a template on which tropoelastin is deposited. Fibrillin-1 is the major component of microfibrils. It is not clear whether elastic fiber-associated molecules, such as fibulins, contribute to tropoelastin deposition. Among the fibulin family, fibulin-2, -4 and -5 are capable of binding to trop...
متن کاملFibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.
OBJECTIVE Recent findings on the role of fibulin-5 (Fbln5) have provided substantial progress in understanding the molecular mechanism of elastic fiber assembly in vitro. However, little is known about differential roles of fibulins in the elastogenesis of blood vessels. Here, we generated double knockout mice for Fbln5 and Fbln2 (termed DKO) and examined the role of fibulins-2 and -5 in develo...
متن کاملInteraction between angiogenin and fibulin 1: evidence and implication.
Angiogenin is an angiogenic factor involved in tumorigenesis. However, the mechanism of angiogenin's action remains elusive. In the present study, we identified fibulin 1, an extracellular matrix and plasma glycoprotein, as an angiogenin-interacting molecule by yeast two-hybrid screening. This interaction was further confirmed by two different approaches. First, fibulin 1 was co-immunoprecipita...
متن کاملFibulin-1 Is Downregulated Through Promoter Hypermethylation in Colorectal Cancer
Fibulin-1 (FBLN1) is involved in the progression of some types of cancer. However, the role of FBLN1 in colorectal cancer (CRC) has not been examined. The purpose of this study was to understand the molecular mechanisms and clinical significance of FBLN1 inactivation in CRC. The expression of FBLN1 in CRC tissues and adjacent normal tissues was analyzed by immunohistochemical analysis and quant...
متن کاملFibulin-2 is dispensable for mouse development and elastic fiber formation.
Fibulin-2 is an extracellular matrix protein belonging to the five-member fibulin family, of which two members have been shown to play essential roles in elastic fiber formation during development. Fibulin-2 interacts with two major constituents of elastic fibers, tropoelastin and fibrillin-1, in vitro and localizes to elastic fibers in many tissues in vivo. The protein is prominently expressed...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1996
ISSN: 1058-8388,1097-0177
DOI: 10.1002/(sici)1097-0177(199603)205:3<348::aid-aja13>3.0.co;2-0